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HLA-E
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, NK-cells, Hepatic stellate cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, U-266/70)
Interaction
Forms a heterotrimer with B2M and a self- or a pathogen-derived peptide (peptide-bound HLA-E-B2M) (PubMed:18339401, 30087334). Similarly to MHC class Ia assembly, HLA-E-B2M heterodimer interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for peptide loading and translocation to the cell surface (PubMed:9427624). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9427624). The optimum binding peptide is a nonamer (VL9) that is primarily derived from amino-acid residues 3-11 of the signal sequences of most HLA-A, -B, -C and -G molecules (PubMed:9754572, 18083576, 9660937, 18339401). The VL9 peptide anchors to five main sites in the peptide-binding groove of HLA-E (PubMed:18339401). Peptide-bound HLA-E-B2M complex interacts with KLRD1-KLRC1 receptor on NK cells (PubMed:9486650, 18083576). Binds with lower affinity to activating KLRD1-KLRC2 (PubMed:18083576, 23335510). The common subunit KLRC1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). Peptide-bound HLA-E-B2M interacts with the alpha-beta TCR on unconventional CD8+ T cells (PubMed:16474394). Peptide-free HLA-E interacts with HLA-F-B2M complex; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I open conformers (OCs).
More Types Infomation
- PE-A*02:01/Human HLA-E (MVDGTLLLL) MHC Tetramer (MHC-LC1930)
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- Class: Class I
- Antigen: HLA-E
- Antigen Species: Human
- Peptide: MVDGTLLLL
- Conjugate: PE
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- Species Reactivity: Human
- Application: IHC-P, WB
- Recombinant Human Anti-human HLA-E Antibody Fab Fragment (MHH-504-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, FC, FuncS
- Recombinant Anti-human HLA-E Antibody (MOB-504)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IF, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IF, FuncS
- Recombinant Anti-human HLA-E Antibody scFv Fragment (MOB-504-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-human HLA-E Antibody Fab Fragment (MOB-504-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, IP, FuncS
- Mouse Anti-HLA-E Recombinant Antibody (clone F21-2) (NEUT-910CQ)
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- Species Reactivity: Avian, Chicken, Turkey
- Type: Mouse IgG1, κ
- Application: WB, Neut, FC, IHC, IHC-Fr, IP
- Recombinant Human Anti-human HLA-E Antibody scFv Fragment (MHH-504-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, FuncS, Neut, ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, FC
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For Research Use Only. Not For Clinical Use.