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HLA-G
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
Protein class
Cancer-related genes
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Not detected
Interaction
Forms a heterotrimer with B2M and a self-peptide (peptide-bound HLA-G-B2M) (PubMed:7584149, PubMed:8805247). HLA-G-B2M complex interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for loading of high affinity peptides and heterotrimer translocation to the cell surface (PubMed:7584149). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9640257). Interacts with COPB1; this interaction mediates the endoplasmic reticulum (ER) retrieval of HLA-G-B2M complexes that bind low affinity peptides (PubMed:11520457, PubMed:12582157). On the cell surface, peptide-bound HLA-G-B2M molecules (referred to as monomers) can form disulfide-linked homomultimers, homodimers and homotrimers (PubMed:12454284, PubMed:12874224, PubMed:16455647). Interacts with KIR2DL4; this interaction is direct (PubMed:10190900, PubMed:16366734). Interacts with LILRB1 and LILRB2 receptors; this interaction is direct (PubMed:16455647, PubMed:16366734, PubMed:17056715, PubMed:12853576). Interacts with CD160; this interactions is direct (PubMed:16809620). Interacts with CD8A homodimer; this interaction is direct and might down-regulate T cell receptor signaling (PubMed:12853576). Isoform 2: Forms a non-disulfide-linked homodimer and interacts with LILRB2 (PubMed:28348268).
More Types Infomation
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- Species Reactivity: Human
- Application: ICC, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, ICC, IF, IHC
- Mouse Anti-HLA-G Recombinant Antibody (clone 87G) (NEUT-911CQ)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a, κ
- Application: WB, Neut, ELISA, FC, ICC, IF, CyTOF
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-HLA-G Recombinant Antibody (HPAB-N0136-YC) (HPAB-N0136-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, FC
- Rat Anti-HLA-G Recombinant Antibody; scFv Fragment (HPAB-N0356-YC-S(P)) (HPAB-N0356-YC-S(P))
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- Species Reactivity: Human
- Type: Rat scFv
- Application: ELISA
- Rat Anti-HLA-G Recombinant Antibody (HPAB-N0356-YC) (HPAB-N0356-YC)
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- Species Reactivity: Human
- Type: Rat IgG
- Application: ELISA
- Mouse Anti-HLA-G Recombinant Antibody; Fab Fragment (HPAB-N0136-YC-F(E)) (HPAB-N0136-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-HLA-G Recombinant Antibody; scFv Fragment (HPAB-N0136-YC-S(P)) (HPAB-N0136-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Rat Anti-HLA-G Recombinant Antibody; Fab Fragment (HPAB-N0356-YC-F(E)) (HPAB-N0356-YC-F(E))
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- Species Reactivity: Human
- Type: Rat Fab
- Application: ELISA
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For Research Use Only. Not For Clinical Use.