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HNRNPA2B1
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer; dimerization is required for nucleocytoplasmic translocation (PubMed:31320558). Identified in the spliceosome C complex (PubMed:11991638). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with IGF2BP1 (PubMed:17289661). Interacts with C9orf72 (PubMed:24549040). Interacts with DGCR8 (PubMed:26321680). Interacts with TARDBP (PubMed:19429692). Interacts with CKAP5 (PubMed:15703215). Interacts with TBK1 (PubMed:31320558). Interacts with STING1 (PubMed:31320558). Interacts with SRC (PubMed:31320558). Interacts with PPIA/CYPA (PubMed:25678563).
Molecular function
Ribonucleoprotein, RNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b, κ
- Application: WB, IP, IF, IHC-P, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, ICC, IF, IHC, IP
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- Species Reactivity: Chicken, Human, Mouse, Rat, Pig
- Type: Mouse IgG2a
- Application: IF, IHC-P, WB
- Mouse Anti-HNRNPA2B1 Recombinant Antibody (clone GLC82C238); Fab Fragment (HPAB-0142-CN-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, IHC
- Mouse Anti-HNRNPA2B1 Recombinant Antibody (clone GLC82C238); scFv Fragment (HPAB-0142-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, IHC
- Mouse Anti-HNRNPA2B1 Recombinant Antibody (clone GLC82C238) (HPAB-0142-CN)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IHC
- Mouse Anti-HNRNPA2B1 Antibody (clone GLC82C238), mRNA (HPAB-0142-CN-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.