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HOXB4
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Collecting duct cells, NK-cells, Basal squamous epithelial cells, Glandular and luminal cells, Hepatic stellate cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (EFO-21, HMC-1, K-562)
Molecular function
Developmental protein, DNA-binding
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, IP, WB
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG2a
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.