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HOXC11

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes, Plasma proteins, Transcription factors

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Proximal enterocytes, Melanocytes, Spermatocytes, Distal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AN3-CA, BJ hTERT+, HaCaT, HeLa, T-47d)

Molecular function

Developmental protein, DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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