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HPD

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Proximal tubular cells, Hepatocytes)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Cell line enriched (Hep G2)

Interaction

Homodimer.

Molecular function

Dioxygenase, Oxidoreductase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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