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HRH4
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
FDA approved drug targets, G-protein coupled receptors
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Melanocytes, Spermatocytes, Late spermatids, Club cells, granulocytes, Early spermatids)
Immune cell specificity
Group enriched (basophil, eosinophil)
Cell line specificity
Cell line enhanced (HL-60)
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.