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HSPA2

Engineered Antibody
HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Inflammatory Bowel Disease 3 and Papillary Cystadenocarcinoma. Among its related pathways are Meiosis and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA8.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Extravillous trophoblasts, Basal squamous epithelial cells, Distal tubular cells)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Cell line enhanced (A549, BEWO, BJ hTERT+, CAPAN-2, SCLC-21H)

Interaction

Interacts with FKBP6 (PubMed:18529014). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (By similarity). Interacts with FKBP6 (PubMed:18529014).

Molecular function

Chaperone

More Types Infomation

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