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HTR1A
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Not detected
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (NTERA-2, SCLC-21H)
Interaction
Heterodimer; heterodimerizes with GPER1. Interacts with YIF1B (By similarity).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.