FDA approved drug targets, Transporters
Membrane
Group enriched (Exocrine glandular cells, Pancreatic endocrine cells, Ductal cells)
Group enriched (naive B-cell, plasmacytoid DC, memory B-cell)
Cell line enhanced (CAPAN-2, Daudi, NTERA-2, SCLC-21H)
Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
Ion channel, Ligand-gated ion channel, Receptor
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For Research Use Only. Not For Clinical Use.