Loading...
HTR4
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
Protein class
FDA approved drug targets, G-protein coupled receptors
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IHC
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.