FDA approved drug targets, G-protein coupled receptors
Intracellular, Membrane (different isoforms)
Group enriched (Inhibitory neurons, Excitatory neurons)
Not detected in immune cells
Not detected
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).
G-protein coupled receptor, Receptor, Transducer
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For Research Use Only. Not For Clinical Use.