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ID2
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, monocytes)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (HDLM-2, HEK93)
Interaction
Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with NR0B2. Interacts with CLOCK and ARNTL/BMAL1.
Molecular function
Developmental protein, Repressor
More Types Infomation
- Recombinant Mouse Anti-Human ID2 Antibody (MOB-2315MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
- Rabbit Anti-ID2 Polyclonal Antibody (MRO-1953-CN) (MRO-1953-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
- Mouse Anti-ID2 Recombinant Antibody (clone A4-D4) (MRO-0809-CN)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2b
- Application: WB, IF, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
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For Research Use Only. Not For Clinical Use.