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ID3

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Protein class

Cancer-related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Adipocytes, Hepatic stellate cells, Ionocytes, Basal respiratory cells)

Immune cell specificity

Immune cell enhanced (memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced (U-698)

Interaction

Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation (By similarity). Interacts with CLOCK and ARNTL/BMAL1.

Molecular function

Repressor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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