Enzymes, FDA approved drug targets, Plasma proteins
Intracellular, Secreted (different isoforms)
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Homodimer (PubMed:17051221, 19321446, 23922390, 26394692, 29596046) (Probable). Can also form homotetramers (By similarity). (Microbial infection) Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus (PubMed:17055432, 17553876).
Allosteric enzyme, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor
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For Research Use Only. Not For Clinical Use.