Disease related genes, Human disease related genes
Intracellular
Group enriched (Late spermatids, Early spermatids)
Immune cell enhanced (memory B-cell)
Low cell line specificity
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity). Interacts with IFT20 (By similarity). Interacts with IFT88 (By similarity). Interacts with IFT80, IFT-81, IFT74, IFT172, TTC30B and KIF17 (By similarity). Interacts with BLOC1S2 (By similarity). Interacts with RYBP (By similarity). Interacts with HOMER1; the interaction possibly prevents the pro-apoptotic effects of IFT57 (By similarity). Interacts with HIP1 (PubMed:11788820). In normal conditions, it poorly interacts with HIP1, HIP1 being strongly associated with HTT (PubMed:11788820). However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57, leading to apoptosis (PubMed:11788820). Interacts with BFAR (PubMed:14502241). Interacts with chicken anemia virus protein apoptin (PubMed:12745083). Interacts with TTC25 (PubMed:25860617).
DNA-binding
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For Research Use Only. Not For Clinical Use.