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IGFBP2

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.
IGFBP2
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Theca cells, Granulosa cells, Endometrial stromal cells, Hepatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, HMC-1, NB-4)

Interaction

Binds IGF2 more than IGF1.

Molecular function

Growth factor binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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