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IGFBP7

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
Protein class

Disease related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Peritubular cells, Leydig cells, Sertoli cells, Smooth muscle cells)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, hTERT-RPE1, RPTEC TERT1, TIME)

Interaction

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

Molecular function

Growth factor binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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