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IKZF1
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (dendritic cells, T-cells, NK-cells, Plasma cells, B-cells, monocytes, Microglial cells, Erythroid cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, HMC-1, JURKAT, MOLT-4, REH, U-698)
Interaction
Heterodimer formed by the various isoforms; this modulates transcription regulator activity (PubMed:17135265, PubMed:17934067). Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 (PubMed:10978333). Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts directly with the CHD4 component of the NuRD complex. Interacts directly with SMARCA4; the interaction associates IKFZ1 with the BAF complex (PubMed:10204490). Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3. Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression. Interacts, to a lesser extent, with PIAS3. Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with IKZF3 (By similarity).
Molecular function
Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, WB
- Rabbit Anti-IKZF1 Recombinant Antibody (clone JB50-38) (MRO-0821-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IP
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- Species Reactivity: Human, Hamster
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Dog
- Type: Mouse IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Species Reactivity: Human, Mouse, Dog
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.