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IL10RA

The IL-10 Receptor alpha (IL-10Rα) antibodies are used for treating a pathogen infection, pathogen reactivation or for vaccination or immunization.
Protein class

CD markers, Disease related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Kupffer cells, monocytes, Langerhans cells, Plasma cells, Macrophages, NK-cells, T-cells, Extravillous trophoblasts, dendritic cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)

Interaction

Interacts with IL10 (PubMed:16982608, 15837194). Interacts with IL10RB (PubMed:16982608). Interacts (via its cytoplasmic domain) with JAK1 (via N-terminus) (PubMed:12133952). Interacts with BTRC; this interaction leads to IL10RA ubiquitination and subsequent degradation (PubMed:22087322). Interacts with STAT3 (By similarity). (Microbial infection) Interacts with human cytomegalovirus protein IL10. (Microbial infection) Interacts with Epstein-Barr virus protein IL10.

Molecular function

Receptor

More Types Infomation
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Function study

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