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IL1RAP
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Hepatocytes, Extravillous trophoblasts)
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Cell line enriched (SK-MEL-30)
Interaction
The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Isoform 4 interacts with IL1R1 in an interleukin-1-dependent manner. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).
Molecular function
Hydrolase, Receptor
More Types Infomation
Related Diseases
Maturity Onset Diabetes of the Young
- Recombinant Human Anti-human IL1RAP Antibody Fab Fragment (MHH-559-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, FC, FuncS
- Recombinant Human Anti-human IL1RAP Antibody scFv Fragment (MHH-559-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, IHC, FuncS
- Recombinant Anti-human IL1RAP Antibody scFv Fragment (MOB-559-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, IP, FuncS
- Recombinant Anti-human IL1RAP Antibody Fab Fragment (MOB-559-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, ELISA, FuncS
- Recombinant Anti-human IL1RAP Antibody (MOB-559)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, FC
- Human Anti-IL1RAP Recombinant Antibody (HPAB-M0110-YC) (HPAB-M0110-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
- Human Anti-IL1RAP Recombinant Antibody (HPAB-M0109-YC) (HPAB-M0109-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, ELISA
- Anti-Human IL1RAP Recombinant Antibody (4B6) (TAB-0382CL)
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- Application: ELISA, FC
- Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0109-YC-F(E)) (HPAB-M0109-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, ELISA
- Mouse Anti-Human IL1RAP Recombinant Antibody (TAB-0381CL)
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- Application: ELISA, FC, FuncS
- Anti-Human IL1RAP Recombinant Antibody (1F5) (TAB-0380CL)
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- Application: ELISA, FC
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- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, ELISA
- Anti-Human IL1RAP Recombinant Antibody scFv Fragment (4B6) (TAB-0382CL-S(P))
-
- Application: ELISA, FC
- Anti-Human IL1RAP Recombinant Antibody scFv Fragment (TAB-0381CL-S(P))
-
- Application: ELISA, FC, FuncS
- Anti-Human IL1RAP Recombinant Antibody scFv Fragment (1F5) (TAB-0380CL-S(P))
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- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.