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IL27RA

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (NK-cells, T-cells, dendritic cells, B-cells, Langerhans cells, Kupffer cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR which interacts with the neuroprotective peptide humanin.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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