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IL32

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Protein class

Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Pancreatic endocrine cells, T-cells, Ductal cells, Exocrine glandular cells)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Cell line enhanced (CACO-2, CAPAN-2, HDLM-2, Hep G2, Karpas-707, MOLT-4, RH-30, U-937)

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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