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IL4R
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Protein class
Cancer-related genes, CD markers, FDA approved drug targets, Human disease related genes, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (granulocytes, B-cells)
Immune cell specificity
Immune cell enhanced (naive B-cell)
Cell line specificity
Cell line enhanced (Daudi, HBEC3-KT, HDLM-2, U-698)
Interaction
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity). Interacts with JAK3 (PubMed:7538655). Interacts with CLM1 (By similarity).
Molecular function
Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, IHC, FuncS
- Human Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-0347LY-F(E)) (HPAB-0347LY-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA
- Human Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-0346LY-F(E)) (HPAB-0346LY-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA
- Human Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-0345LY-F(E)) (HPAB-0345LY-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA
- Human Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-0344LY-F(E)) (HPAB-0344LY-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: Block, ELISA
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1459LY-F(E)) (HPAB-1459LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1458LY-F(E)) (HPAB-1458LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1457LY-F(E)) (HPAB-1457LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1456LY-F(E)) (HPAB-1456LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1455LY-F(E)) (HPAB-1455LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1454LY-F(E)) (HPAB-1454LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1453LY-F(E)) (HPAB-1453LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1452LY-F(E)) (HPAB-1452LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1451LY-F(E)) (HPAB-1451LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1450LY-F(E)) (HPAB-1450LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1449LY-F(E)) (HPAB-1449LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1448LY-F(E)) (HPAB-1448LY-F(E))
-
- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Mouse Anti-IL4R Recombinant Antibody; Fab Fragment (HPAB-1447LY-F(E)) (HPAB-1447LY-F(E))
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- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse Fab
- Application: FC, ELISA, Block
- Human Anti-IL4R Recombinant Antibody (HPAB-0071-WJ-F(E)); Fab Fragment (HPAB-0071-WJ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
- Human Anti-IL4R Recombinant Antibody (clone Antibody 1); Fab Fragment (HPAB-0291-YC-F(E))
-
- Derivation: Phage display library
- Species Reactivity: Human, Cynomolgus
- Type: Human Fab
- Application: HTRF, FuncS
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For Research Use Only. Not For Clinical Use.