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INHA

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients.
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts, Granulosa cells, Theca cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, HEL, SK-BR-3, SuSa)

Interaction

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

Molecular function

Growth factor, Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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