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INHBA
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Smooth muscle cells, Syncytiotrophoblasts, Leydig cells, Granulosa cells, Langerhans cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HBEC3-KT, hTEC/SVTERT24-B, hTERT-HME1, hTERT-RPE1, TIME, U-138 MG)
Interaction
Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.
Molecular function
Growth factor, Hormone
More Types Infomation
- Recombinant Anti-human INHBA Antibody (MOB-578)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: FC, IP, FuncS
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: Neut, WB
- Recombinant Human Anti-human INHBA Antibody scFv Fragment (MHH-578-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-human INHBA Antibody scFv Fragment (MOB-578-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
- Recombinant Anti-human INHBA Antibody Fab Fragment (MOB-578-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, IP, FuncS
- Recombinant Human Anti-human INHBA Antibody Fab Fragment (MHH-578-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: IF, WB, FuncS
-
- Species Reactivity: Rat, Human
- Type: Mouse IgG1
- Application: WB, Neut
- Mouse Anti-INHBA Recombinant Antibody (clone CBL821) (NEUT-1527CQ)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: ELISA, Neut
- Mouse Anti-INHBA Recombinant Antibody (clone CBL138) (NEUT-1526CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-INHBA Recombinant Antibody (clone E4) (EPAF-0748LC)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB
-
- Species Reactivity: Human, Rat, Hamster
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.