Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Macrophages, Kupffer cells, Microglial cells, monocytes, Adipocytes)
Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, neutrophil, basophil, myeloid DC)
Cell line enhanced (ASC diff, ASC TERT1, HEL, HL-60, NB-4, THP-1, U-937)
Monomer (PubMed:33238146). Homodimer; disulfide-linked (PubMed:33238146). May interact with IRAK4 (when phosphorylated) (PubMed:33238146). Interacts (when phosphorylated at Ser-110) with PIN1 (via WW domain) in response to IL33-mediated (but not TLR4 ligand LPS) dendritic cell stimulation (PubMed:29686383).
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For Research Use Only. Not For Clinical Use.