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IRF1

The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
IRF1
Protein class

Cancer-related genes, Disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Skeletal myocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HHSteC, REH)

Interaction

Monomer (By similarity). Homodimer (By similarity). Interacts with EP300 (PubMed:15509808). Interacts with MYD88 (By similarity). Interacts with PIAS3 (By similarity).

Molecular function

Activator, DNA-binding, Repressor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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