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IRF9
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
Protein class
Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, GAMG)
Interaction
Interacts with STAT2 in the cytoplasm. Forms the interferon-stimulated gene factor 3 complex (ISGF3) with the heterodimer STAT1:STAT2; upon stimulation.
Molecular function
Activator, DNA-binding
More Types Infomation
- Recombinant Mouse Anti-Human IRF9 Antibody (MOB-0995MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC, WB
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For Research Use Only. Not For Clinical Use.