Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
Loading...
Custom Services order now ship next day

ISL1

Engineered Antibody
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Bipolar cells, Enteroendocrine cells, Horizontal cells, Cytotrophoblasts, Syncytiotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (SH-SY5Y)

Interaction

At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts with POU3F2. Interacts with POU4F3. Interacts (via N-terminal domain) with MLIP; the interaction represses ISL1 transactivator activity (By similarity).

Molecular function

Activator, Developmental protein, DNA-binding

More Types Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart
    Inquiry

    Go to compare