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ITGAD

This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants.
Protein class

CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Kupffer cells, T-cells, Macrophages, dendritic cells, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.

Molecular function

Integrin, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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