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ITIH2
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).
Protein class
Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Hep G2)
Interaction
I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin.
Molecular function
Protease inhibitor, Serine protease inhibitor
More Types Infomation
- Recombinant Anti-Human ITIH2 Antibody scFv Fragment (MOB-3759z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-Human ITIH2 Antibody Fab Fragment (MOB-3759z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, IF, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ICC, IP
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For Research Use Only. Not For Clinical Use.