Disease related genes, Human disease related genes, Potential drug targets, Transporters
Intracellular, Membrane, Secreted (different isoforms)
Low cell type specificity
Immune cell enhanced (neutrophil)
Cell line enhanced (HMC-1, RPTEC TERT1)
Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40.
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For Research Use Only. Not For Clinical Use.