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JUND
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]JUND (JunD Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUND include T-Cell Leukemia and Adult T-Cell Leukemia. Among its related pathways are ERK Signaling and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is JUN.
Protein class
Cancer-related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer; binds DNA as a heterodimer (PubMed:28981703). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (PubMed:28981703). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505, 22327296). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (PubMed:22327296).
Molecular function
Activator, DNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP
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- Species Reactivity: Human, Primate
- Type: IgG
- Application: WB, IF, ICC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IP
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
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For Research Use Only. Not For Clinical Use.