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KARS
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Extravillous trophoblasts, Cytotrophoblasts, Syncytiotrophoblasts, Cardiomyocytes, Hofbauer cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer and tetradimer (PubMed:18272479, PubMed:23159739, PubMed:26074468, PubMed:28887846). Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, PubMed:24312579, PubMed:23159739). Interacts with AIMP2 (via N-terminus) and MITF (PubMed:9878398, PubMed:14975237, PubMed:15220430, PubMed:23159739, PubMed:26074468, PubMed:31116475). Interacts with TARSL2 (PubMed:24312579). (Microbial infection) Interacts directly with HIV-1 virus GAG protein (PubMed:12756246, PubMed:15220430).
Molecular function
Aminoacyl-tRNA synthetase, Ligase, Transferase
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP, IF
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP, FC
- Human Anti-KARS Recombinant Antibody (TAB-0631CL) (TAB-0631CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA
- Human Anti-KARS Recombinant Antibody; Fab Fragment (TAB-0631CL-F(E)) (TAB-0631CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
- Human Anti-KARS Recombinant Antibody; scFv Fragment (TAB-0631CL-S(P)) (TAB-0631CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.