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KCNC2
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, FDA approved drug targets, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNC1. Interacts with KCNC1. Homotetramer or heterotetramer channel activity is regulated by association with modulating ancillary subunits such as KCNE1, KCNE2 and KCNE3, creating a functionally diverse range of channel complexes. Interacts with KCNE1, KCNE2 and KCNE3.
Molecular function
Ion channel, Potassium channel, Voltage-gated channel
More Types Infomation
- Chicken Anti-KCNC2 Polyclonal IgY (BRD-0309MZ)
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- Species Reactivity: Human, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.