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KCNC3
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Endometrial ciliated cells, Collecting duct cells, Inhibitory neurons, Glandular and luminal cells, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (CACO-2, CAPAN-2, HDLM-2, HMC-1, K-562, SK-BR-3, T-47d, U-2 OS)
Interaction
Homotetramer. Heterotetramer with KCNC1 (PubMed:23734863). Interacts (via C-terminus) with HAX1 (PubMed:26997484). Identified in a complex with ACTR3, a subunit of the Arp2/3 complex; this interaction is indirect and depends on the presence of HAX1 (PubMed:26997484). Interaction with HAX1 modulates channel gating (PubMed:26997484).
Molecular function
Ion channel, Potassium channel, Voltage-gated channel
More Types Infomation
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- Species Reactivity: Human
- Application: ICC/IF, WB
- Recombinant Human Anti-KCNC3 Soluble TCR (MA3) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1879)
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- Epitope: FLPDLNVNA
- MHC: HLA-A2
- Human Anti-KCNC3 Recombinant Soluble TCR (clone MA3) (scTCR-0578YC-S(P))
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- Epitope: FLPDLNVNA
- MHC: HLA-A2
- Recombinant Human Anti-KCNC3 Soluble TCR (MA3) (C-Cys) (VS-0622-YF4587)
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- Epitope: FLPDLNVNA
- MHC: HLA-A2
- Recombinant Human Anti-KCNC3 Soluble TCR (MA3) (KIH) (VS-0622-YF7295)
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- Epitope: FLPDLNVNA
- MHC: HLA-A2
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For Research Use Only. Not For Clinical Use.