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KCND3
KCND3 (Potassium Voltage-Gated Channel Subfamily D Member 3) is a Protein Coding gene. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Diseases associated with KCND3 include Spinocerebellar Ataxia 19 and Brugada Syndrome 9.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Bipolar cells, Oligodendrocyte precursor cells, Cardiomyocytes, Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (OE19, SCLC-21H, U-2 OS, WM-115)
Interaction
Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with KCNE1, KCNE2, SCN1B and KCNAB1 and DLG1.
Molecular function
Ion channel, Potassium channel, Voltage-gated channel
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC, IP
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- Species Reactivity: Human
- Application: ICC/IF, WB, IP, IHC-P, IHC-Fr
- Rabbit Anti-KCND3 Polyclonal Antibody (MRO-2004-CN) (MRO-2004-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Rabbit Anti-KCND3 Recombinant Antibody (VS-0522-LC160) (VS-0522-LC160)
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- Species Reactivity: Rat, Frog, Human, Mouse
- Type: Rabbit IgG
- Application: IB, IHC
- Human Anti-KCND3 Recombinant Antibody (VS-0522-LC159) (VS-0522-LC159)
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- Species Reactivity: Rat, Frog, Human, Mouse
- Type: Human IgG1
- Application: IB, IHC
- Rat Anti-KCND3 Recombinant Antibody (VS-0522-LC158) (VS-0522-LC158)
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- Species Reactivity: Rat, Frog, Human, Mouse
- Type: Rat IgG2b
- Application: IB, IHC
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For Research Use Only. Not For Clinical Use.