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KCNH1
The antibody which specifically binds to/interacts with EAG1 ion channel can be used for the treatment of a hyperproliferative disease, inflammatory disease, psoriasis, or a neurodegenerative disease.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters, Voltage-gated ion channels
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (LHCN-M2, RH-30, RPTEC TERT1, SH-SY5Y, SK-MEL-30, T-47d)
Interaction
The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2 (PubMed:11943152). Interacts with ALG10B (By similarity). Interacts with RABEP1 (By similarity). Interacts (via C-terminus) with CTTN (PubMed:23144454). Interacts (via C-terminal cytoplasmic region) with Ca(2+)-bound calmodulin (PubMed:10880439, PubMed:27325704, PubMed:27618660). Interacts with the spider kappa-theraphotoxin-Aa1a and mu/kappa-theraphotoxin-Ap1a (PubMed:30149017).
Molecular function
Calmodulin-binding, Ion channel, Potassium channel, Voltage-gated channel
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
- Anti-Human KCNH1 Recombinant Antibody (TAB-467CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
- Mouse Anti-KCNH1 Recombinant Antibody (clone ImAB5); Fab Fragment (HPAB-1773-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Inhib, IF, IHC
- Mouse Anti-KCNH1 Recombinant Antibody (clone ImAB5); scFv Fragment (HPAB-1773-FY-F(E))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib, IF, IHC
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- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Mouse Anti-KCNH1 Recombinant Antibody (clone ImAB5) (HPAB-1773-FY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: Inhib
- Human Anti-KCNH1 Antibody, mRNA (TAB-467CL-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.