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KCNH6
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms.
Protein class
FDA approved drug targets, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Group enriched (Bipolar cells, Proximal enterocytes, Enteroendocrine cells, Cone photoreceptor cells, Cardiomyocytes, Proximal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (SCLC-21H, SH-SY5Y)
Interaction
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3 (By similarity).
Molecular function
Ion channel, Potassium channel, Voltage-gated channel
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.