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KCNIP3

CSEN, also known as calsenilin and KCNIP3, is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS.
Protein class

Transporters

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Peritubular cells, Excitatory neurons, Leydig cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A-431, BJ hTERT+, hTERT-RPE1, RPTEC TERT1, U-138 MG)

Interaction

Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium (PubMed:17962406). Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1. Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 and KCND3.

Molecular function

Ion channel, Potassium channel, Repressor, Voltage-gated channel

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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