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KCNT1

KCNT1 (Potassium Sodium-Activated Channel Subfamily T Member 1) is a Protein Coding gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Diseases associated with KCNT1 include Developmental And Epileptic Encephalopathy 14 and Epilepsy, Nocturnal Frontal Lobe, 5.
Protein class

Disease related genes, Human disease related genes, Potential drug targets, Transporters, Voltage-gated ion channels

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Excitatory neurons, Inhibitory neurons, Theca cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (OE19, RPMI-8226, SCLC-21H)

Interaction

Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (PubMed:20512134). Interacts with CRBN via its cytoplasmic C-terminus (By similarity).

Molecular function

Ion channel, Potassium channel

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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