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KCTD12
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Kupffer cells, Enteroendocrine cells, Adipocytes, Macrophages, Hofbauer cells, monocytes, Endothelial cells)
Immune cell specificity
Immune cell enhanced (classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (ASC diff, HUVEC TERT2, TIME)
Interaction
Interacts as a tetramer with GABRB1 and GABRB2.
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.