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KDM1A
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of a histone demethylase complex with RCOR1 (PubMed:20389281, PubMed:23721412, PubMed:16885027, PubMed:21300290). Component of a RCOR/GFI/KDM1A/HDAC complex (PubMed:12032298, PubMed:11102443). Interacts directly with GFI1 and GFI1B. Interacts with INSM1 (via N-terminus) (PubMed:23721412). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I (PubMed:12493763, PubMed:16140033, PubMed:16885027). In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity (PubMed:16079794, PubMed:16956976). Interacts with the androgen receptor (AR) (PubMed:16079795). Interacts with SNAI1 (via SNAG domain) (PubMed:20389281, PubMed:20562920, PubMed:21300290, PubMed:23721412). Interacts (via AOD/Tower domain) with JADE2 (via C-terminus) (PubMed:25018020). Interacts with ESRRB; co-occupes the core set of ESRRB targets (By similarity). Interacts with SAMD1 (via WH domain); the interaction modulates KDM1A function (PubMed:33980486).
Molecular function
Chromatin regulator, Developmental protein, Oxidoreductase, Repressor
More Types Infomation
- Rabbit Anti-KDM1A Polyclonal Antibody (MRO-2018-CN) (MRO-2018-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Recombinant Mouse Anti-Human KDM1A Antibody (MOB-2167MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ELISA, ICC/IF, IP, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- Derivation: Mouse
- Species Reactivity: Human, Monkey
- Type: Mouse IgG1
- Application: WB, ICC, IP
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat, Pig
- Type: Mouse IgG
- Application: ELISA, WB
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- Species Reactivity: Human, Hamster, Rat
- Type: Rabbit IgG
- Application: WB, IF, IP
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.