Loading...
KDM5B
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Interacts (via PHD-type 1 zinc finger) with histone H3 unmodified at 'Lys-4'; the interaction is inhibited when histone H3 is methylated at 'Arg-2' or 'Lys-4' (PubMed:24952722).
Molecular function
Chromatin regulator, Dioxygenase, Oxidoreductase, Repressor
More Types Infomation
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA, FuncS
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF
- Recombinant Mouse Anti-Human KDM5B Antibody (MOB-1433MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-P, WB
- Rabbit Anti-KDM5B Polyclonal Antibody (MRO-1992-CN) (MRO-1992-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, FC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.