KHDRBS3

Intracellular

Cell type enhanced (Excitatory neurons, Oligodendrocyte precursor cells, Early spermatids, Spermatocytes, Microglial cells, Inhibitory neurons)

Immune cell enriched (eosinophil)

Cell line enhanced (REH, RPTEC TERT1, WM-115)

Self-associates to form homooligomers; dimerization increases RNA affinity (PubMed:26758068). Interacts with KHDRBS2/SLM-1 (By similarity). Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity (PubMed:10332027). Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts with HNRPL (By similarity). Interacts with RBMX, RBMY1A1, p85 subunit of PI3-kinase, SERPINB5 (PubMed:10564820, PubMed:10332027, PubMed:10749975, PubMed:21725612). Interacts with SIAH1 which promotes targeting for degradation (PubMed:15163637).

RNA-binding