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KIRREL3
Kirrel3 is a Protein Coding gene. The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Diseases associated with Kirrel3 include Autosomal Dominant Non-Syndromic Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 4.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Group enriched (Inhibitory neurons, Oligodendrocytes, Excitatory neurons)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, U-138 MG, U-251 MG)
Interaction
Homodimer; mediates homophilic interactions to promote cell adhesion. Interacts with NPHS1; forms heterodimers with NPHS1 (By similarity). Interacts with NPHS2/podocin (via the C-terminus) (PubMed:12424224). Interacts with CASK (PubMed:19012874). Interacts (via extracellular region) with MAP1B (PubMed:25902260). Interacts (via extracellular region) with MYO16 (PubMed:25902260). Interacts (via intracellular region) with ATP1B1 (PubMed:25902260). Interacts (via intracellular region) with SHMT2 (PubMed:25902260). Interacts (via intracellular region) with UFC1 (PubMed:25902260).
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human, Does not react with Mouse
- Type: IgG
- Application: WB
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ICC, WB, IHC
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: ICC, WB, IHC
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- Species Reactivity: Rat, Mouse
- Type: Rabbit IgG
- Application: IHC
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- Species Reactivity: Rat, Mouse
- Type: Rat IgG2b
- Application: IHC
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- Species Reactivity: Rat, Mouse
- Type: Mouse IgG1
- Application: IHC
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For Research Use Only. Not For Clinical Use.