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KL
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Proximal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HMC-1, SK-BR-3)
Interaction
Homodimer. Interacts with FGF23 and FGFR1.
Molecular function
Glycosidase, Hormone, Hydrolase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P, WB
- Recombinant Rat Anti-KL Antibody (CBL652) (NEUT-1636CQ)
-
- Species Reactivity: Human
- Type: IgG2b
- Application: Neut
- Recombinant Human Anti-human KL Antibody scFv Fragment (MHH-602-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
- Recombinant Rabbit Anti-KL Monoclonal Antibody (JM93-76) (MRO-0903-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
- Recombinant Human Anti-human KL Antibody Fab Fragment (MHH-602-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, IF, FuncS
- Recombinant Human Anti-human KL Antibody (MHH-602)
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: IP, FuncS
- Recombinant Anti-human KL Antibody scFv Fragment (MOB-602-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
- Recombinant Anti-human KL Antibody Fab Fragment (MOB-602-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, IF, FuncS
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For Research Use Only. Not For Clinical Use.