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KLF11
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Suprabasal keratinocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
Interacts with SIN3A.
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.