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KLF2

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability.
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Adipocytes, Plasma cells, B-cells, Gastric mucus-secreting cells, dendritic cells, Endothelial cells, NK-cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (RPMI-8226, TIME, U-266/70, U-266/84)

Interaction

Interacts with WWP1.

Molecular function

Activator, DNA-binding

More Types Infomation

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