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KLK1

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Protein class

Enzymes, Metabolic proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Intestinal goblet cells, Exocrine glandular cells)

Immune cell specificity

Group enriched (memory B-cell, naive B-cell)

Cell line specificity

Cell line enriched (RPMI-8226)

Molecular function

Hydrolase, Protease, Serine protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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